An inhibitor of microtubule polymerization
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Biochemicals

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Cancer
Cell Biology
Cytoskeleton & Motor Proteins

ABT-751

Item No. 22935

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-benzenesulfonamide
CAS Number
141430-65-1
Molecular Formula
C18H17N3O4S
Formula Weight
371.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
244, 280 nm
SMILES
COC1=CC=C(S(NC2=CC=CN=C2NC3=CC=C(O)C=C3)(=O)=O)C=C1
InChi Code
InChI=1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20)
InChi Key
URCVCIZFVQDVPM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $158

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    50 mg

    $609

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    Cayman Chemical
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    Product Description

    ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM).1 It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models.2 It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshimatsu, K., Yamaguchi, A., Yoshino, H., et al. Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin. Cancer Res. 57(15), 3208-3213 (1997).

    2. Morton, C.L., Favours, E.G., Mercer, K.S., et al. Evaluation of ABT-751 against childhood cancer models in vivo. Invest. New. Drugs 25(4), 285-295 (2007).

    3. Luo, Y., Hradil, V.P., Frost, D.J., et al. ABT-751, a novel tubulin-binding agent, decreases tumor perfusion and disrupts tumor vasculature. Anticancer Drugs 20(6), 483-492 (2009).